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New response surface model and its applications in aerodynamic optimization of axial compressor blade profile

LIU Xiaojia, NING Fangfei

《能源前沿（英文）》 2008年第2卷第4期页码 541-549 doi: 10.1007/s11708-008-0077-3

摘要： A parametric method for the axial compressor 2D blade profiles is proposed in which the blade geometries are defined with the parameters commonly used for blade definition, which ensures that the geometric significance is clear and an unreasonable blade profile is not generated. Several illustrations are presented to show the fitting precision of the method. A novel response surface model is proposed which regards the objective distribution function in the vicinity of a sample as normal school, and then generates the response surface function in the whole design space by a linear combination of distribution functions of all the samples. Based on this model, a numerical aerodynamic optimization platform for the axial compressor 2D blade profiles is developed, by which aerodynamic optimization of two compressor blade profiles are presented.

关键词： definition objective distribution fitting precision combination numerical aerodynamic

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Do not let precision medicine be kidnapped

null

《医学前沿（英文）》 2015年第9卷第4期页码 512-513 doi: 10.1007/s11684-015-0425-8

摘要：

Obama’s precision medicine initiative made the medical community boil over after the initiative’s release. Precision medicine has been advocated by the majority of scientists and doctors. However, some experts have questioned this concept. This article does not oppose precision medicine. However, the incentive of vigorously promoting precision medicine at present is a concern.

关键词： precision medicine personalized medicine genomics

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Review on the progress of ultra-precision machining technologies

Julong YUAN, Binghai LYU, Wei HANG, Qianfa DENG

《机械工程前沿（英文）》 2017年第12卷第2期页码 158-180 doi: 10.1007/s11465-017-0455-9

摘要：

Ultra-precision machining technologies are the essential methods, to obtain the highest form accuracy and surface quality. As more research findings are published, such technologies now involve complicated systems engineering and been widely used in the production of components in various aerospace, national defense, optics, mechanics, electronics, and other high-tech applications. The conception, applications and history of ultra-precision machining are introduced in this article, and the developments of ultra-precision machining technologies, especially ultra-precision grinding, ultra-precision cutting and polishing are also reviewed. The current state and problems of this field in China are analyzed. Finally, the development trends of this field and the coping strategies employed in China to keep up with the trends are discussed.

关键词： ultra-precision grinding ultra-precision cutting ultra-precision polishing research status in China development tendency

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复杂地质曲面三维插值—逼近拟合构造方法

李明超,缪正建,刘菲,王刚

《中国工程科学》 2011年第13卷第12期页码 103-107

摘要：

针对水利水电工程多源地质数据的特点，充分考虑了地质精度要求、曲面连续性和数据存储量等多方面的均衡，提出并实现了基于NURBS(non-uniform rational B-splines，非均匀有理样条曲线）技术的复杂地质曲面插值—逼近拟合构造方法。该方法对于工程关键区域集中且均匀分布的原始数据，采用NURBS蒙皮插值方法，使曲面严格通过这些数据点；对于周边区域分布离散的数据，采用NURBS逼近拟合方法，使曲面在给定精度下充分逼近原始数据；最后对整体曲面的地质结构合理性、几何性和精度进行检查分析和调整。实例表明，该方法所构造的地质曲面能满足地质工程师的实际需要，并能为进一步的三维地质建模提供基础。

关键词：地质曲面插值—逼近拟合三维构造多源地质数据

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Self-generation of machining precision and its realization in lapping of super precision solid balls

ZHANG Bopeng

《机械工程前沿（英文）》 2008年第3卷第3期页码 348-353 doi: 10.1007/s11465-008-0065-7

摘要： This paper presents the principle of self-generation of machining precision by explaining its basic concept and five necessary conditions for forming a system with self-organization capability. A self-generation system is a kind of system with self-organization capability. The self-generation of machining precision for solid balls with super precision is emphatically explained. From the viewpoint of self-organization, there are three types of systems including system 1 with the self-regulation capability, 2 with the self-determination capability of goals, and 3 with the self-organization capability. Although they are all closed loop control systems, they have different constructions and functions. Necessary conditions for achieving self-generation of machining precision are given. Establishment of the system for machining solid balls with super precision is discussed. Self-generation of machining precision for solid balls with super precision on the basis of the capability of self-removal of errors is presented. Self-generation includes the ability of self-removal of errors for solid balls, convergence of self-removal of errors, self-generation of precision, and self-generating system for the given.

关键词： self-generation necessary self-regulation capability viewpoint Necessary

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Separation mechanism for double cylinder with shrink fitting system used for ceramics conveying rollers

Wenbin LI, Hiromasa SAKAI, Shota HARADA, Yasushi TAKASE, Nao-Aki NODA

《机械工程前沿（英文）》 2011年第6卷第3期页码 277-286 doi: 10.1007/s11465-011-0234-y

摘要：

Steel conveying rollers used in hot rolling mills must be exchanged frequently at great cost because hot conveyed strips induce wear and deterioration on the surface of roller in short periods. In previous studies, new roller structure was considered which has a ceramics sleeve connected with two steel shafts at both ends by shrink fitting. Here, although the ceramics sleeve can be used for many years, the steel shafts sometimes have to be exchanged for maintenance and reconstruction under the corrosive atmosphere. Since the thermal expansion coefficient of steel is about five times larger than that of ceramics, it is necessary to investigate how to separate the shrink fitting system by heating outside of sleeve and cooling inside of the shaft. Although how to separate the real roller has been discussed in the previous study, the separation mechanism has not been clarified yet. Therefore, in this study, several types of more fundamental models are investigated to understand the separation mechanism of real roller by the application of the finite element method. The results may be useful for designs of new rollers.

关键词： contact ceramics thermal stress heating finite element method

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与地球同步：碳氮循环在保护地球宜居性中面临的挑战 Views & Comments

Robert Socolow

《工程（英文）》 2016年第2卷第1期页码 21-22 doi: 10.1016/J.ENG.2016.01.012

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Human pangenome: far-reaching implications in precision medicine

《医学前沿（英文）》 doi: 10.1007/s11684-023-1039-1

摘要： Human pangenome: far-reaching implications in precision medicine

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Investigating peak stresses in fitting and repair patches of buried polyethylene gas pipes

Reza KHADEMI ZAHEDI, Pouyan ALIMOURI, Hooman KHADEMI ZAHEDI, Mohammad SHISHESAZ

《结构与土木工程前沿（英文）》 2020年第14卷第1期页码 147-168 doi: 10.1007/s11709-019-0587-6

摘要： Nowadays, polyethylene composes a large number of natural gas distribution pipelines installed under the ground. The focus of the present contribution is two fold. One of the objectives is to investigate the applicability of polyethylene fittings in joining polyethylene gas pipes which are electrofused onto the pipe ends and buried under the ground, by estimating stress distribution using finite element method. The second objective is to study the effectiveness of polyethylene repair patches which are used to mend the defected pipelines by performing a finite element analysis to calculate peak stress values. Buried polyethylene pipelines in the natural gas industry, can be imposed by sever loadings including the soil-structure interaction, traffic load, soil’s column weight, internal pressure, and thermal loads resulting from daily and/or seasonal temperature changes. Additionally, due to the application of pipe joints, and repair patches local stresses superimposed on the aforementioned loading effects. The pipe is assumed to be made of PE80 resin and its jointing socket, and the repair patch is PE100 material. The computational analysis of stresses and the computer simulations are performed using ANSYS commercial software. According to the results, the peak stress values take place in the middle of the fitting and at its internal surface. The maximum stress values in fitting and pipe are below the allowable stresses which shows the proper use of introduced fitting is applicable even in hot climate areas of Ahvaz, Iran. Although the buried pipe is imposed to the maximum values of stresses, the PE100 socket is more sensitive to a temperature drop. Furthermore, all four studied patch arrangements show significant reinforcing effects on the defected section of the buried PE gas pipe to transfer applied loads. Meanwhile, the defected buried medium density polyethylene gas pipe and its saddle fused patch can resist the imposed mechanical and thermal loads of 22°C temperature increase. Moreover, increasing the saddle fusion patch length to 12 inches reduces the maximum stress values in the pipe, significantly.

关键词： Ansys software polyethylene buried pipelines polyethylene joints polyethylene patches peak von Mises stress soil-pipe interaction temperature variation

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Highlights in precision agriculture

Chunjiang ZHAO, Minzan LI

《农业科学与工程前沿（英文）》 2018年第5卷第4期页码 391-392 doi: 10.15302/J-FASE-2018246

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High resolution satellite imaging sensors for precision agriculture

Chenghai YANG

《农业科学与工程前沿（英文）》 2018年第5卷第4期页码 393-405 doi: 10.15302/J-FASE-2018226

摘要：

The central concept of precision agriculture is to manage within-field soil and crop growth variability for more efficient use of farming inputs. Remote sensing has been an integral part of precision agriculture since the farming technology started developing in the mid to late 1980s. Various types of remote sensors carried on ground-based platforms, manned aircraft, satellites, and more recently, unmanned aircraft have been used for precision agriculture applications. Original satellite sensors, such as Landsat and SPOT, have commonly been used for agricultural applications over large geographic areas since the 1970s, but they have limited use for precision agriculture because of their relatively coarse spatial resolution and long revisit time. Recent developments in high resolution satellite sensors have significantly narrowed the gap in spatial resolution between satellite imagery and airborne imagery. Since the first high resolution satellite sensor IKONOS was launched in 1999, numerous commercial high resolution satellite sensors have become available. These imaging sensors not only provide images with high spatial resolution, but can also repeatedly view the same target area. The high revisit frequency and fast data turnaround time, combined with their relatively large aerial coverage, make high resolution satellite sensors attractive for many applications, including precision agriculture. This article will provide an overview of commercially available high resolution satellite sensors that have been used or have potential for precision agriculture. The applications of these sensors for precision agriculture are reviewed and application examples based on the studies conducted by the author and his collaborators are provided to illustrate how high resolution satellite imagery has been used for crop identification, crop yield variability mapping and pest management. Some challenges and future directions on the use of high resolution satellite sensors and other types of remote sensors for precision agriculture are discussed.

关键词： high resolution satellite sensor multispectral imagery precision agriculture spatial resolution temporal resolution

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

null

《医学前沿（英文）》 2018年第12卷第2期页码 229-235 doi: 10.1007/s11684-017-0581-0

摘要：

On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.

关键词： molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

《医学前沿（英文）》 2019年第13卷第5期页码 540-546 doi: 10.1007/s11684-018-0637-9

摘要： Given the rapid development in precision medicine, tremendous efforts have been devoted to discovering new biomarkers for disease diagnosis and treatment. Esophageal cancer-related gene-4 ( ), which is initially known as a new candidate tumor suppressor gene, is emerging as a sentinel molecule for gauging tissue homeostasis. ECRG4 is unique in its cytokine-like functional pattern and epigenetically-regulated gene expression pattern. The gene can be released from the cell membrane upon activation and detected in liquid biopsy, thus offering considerable potential in precision medicine. This review provides an updated summary on the biology of ECRG4, with emphasis on its important roles in cancer diagnosis and therapy. The future perspectives of ECRG4 as a potential molecular marker in precision medicine are also discussed in detail.

关键词： ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis

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Application of liquid biopsy in precision medicine: opportunities and challenges

null

《医学前沿（英文）》 2017年第11卷第4期页码 522-527 doi: 10.1007/s11684-017-0526-7

摘要：

Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosis and treatment of individuals. Detecting circulating tumor cell (CTC) or circulating tumor DNA (ctDNA) in plasma or serum could serve as liquid biopsy, which would be useful for numerous diagnostic applications. Liquid biopsies can help clinicians screen and detect cancer early, stratify patients to the most suitable treatment and real-time monitoring of treatment response and resistance mechanisms in the tumor, evaluate the risk for metastatic relapse, and estimate prognosis. We summarized the advantages and disadvantages of tissue and liquid biopsies. We also further compared and analyzed the advantages and limitations of detecting CTCs, ctDNAs, and exosomes. Furthermore, we reviewed the literature related with the application of serum or plasma CTCs, ctDNAs, and exosomes for diagnosis and prognosis of cancer. We also analyzed their opportunities and challenges as future biomarkers. In the future, liquid biopsies could be used to guide cancer treatment. They could also provide the ideal scheme to personalize treatment in precision medicine.

关键词： liquid biopsy circulating tumor cells cell-free ctDNA exosomes precision medicine